Cialis and Viagra: Treating Male Erectile Dysfunction
Gui í a de Salud Masculina
Cialis (tadalafil) and Viagra (sildenafil) are both drugs used to treat male erectile dysfunction (ED). Here are some of their characteristics:
I. the mechanism of action
Identical point
Both of them belong to type 5 phosphodiesterase (PDE5) inhibitors. PDE5 is highly expressed in corpus cavernosum smooth muscle cells of the penis. Normally, PDE5 breaks down cyclic guanosine monophosphate (cGMP). During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the penis. NO activates guanosine cyclase and converts guanosine triphosphate (GTP) into cGMP,cGMP, which causes smooth muscle relaxation of the corpus cavernosum and blood flow into the penis, which leads to erection. Cialis and Viagra help maintain penile erectile function by inhibiting the activity of PDE5 and reducing cGMP degradation.
Differences
Action time
Cialis (Tadalafe)For a long time, it is often referred to as a "long-acting drug", and its effective time can be as long as 36 hours, which means that patients are likely to get and maintain an erection during sexual stimulation for a long time after taking the drug.
Viagra (sildenafil): the action time is relatively short, generally about 4-6 hours, which is a short-acting ED treatment drug.
II. Drug use
Mode of taking
Cialis (Tadalafe)It can be taken as needed, and there is also a regular use of small daily doses. For some patients who want to maintain their sexual ability for a longer period of time, daily low-dose tadalafil can provide a more stable effect.
Viagra (sildenafil): it is usually taken on demand, usually about 1 hour before sexual activity, but it can play a role at any time within 0.5-4 hours before sexual activity.
Dietary influence
Cialis (Tadalafe)The absorption of tadalafil is not affected by food and can be taken on an empty stomach or after eating.
Viagra (sildenafil)A high-fat diet may affect the absorption rate of sildenafil and reduce the rate of its efficacy, so it is generally recommended to take sildenafil on an empty stomach.
Third, adverse reactions
Identical point
Common adverse reactionsBoth may cause similar mild to moderate adverse reactions, such as headache, facial flush, nasal congestion, indigestion, etc., which are usually temporary and diminish as the body adapts to the drug.
Differences
Incidence and severityThere may be individual differences in the incidence and severity of specific adverse reactions. some patients may be more tolerant to tadalafil, and the incidence of adverse reactions such as headache when using tadalafil is relatively low. other patients may have a better reaction to sildenafil and relatively mild adverse reactions when using sildenafil.
IV. Contraindications
-both are prohibited for patients who are using nitrates (such as nitroglycerin) because combination use can lead to severe hypotension and for those who are allergic to drug ingredients.
These drugs must be used under the guidance of a doctor to ensure safety and effectiveness.