The person you want to ask may be tadalafil.
1. Basic information
1、medication type
- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and is a phosphodiesterase type 5 (PDE5) inhibitor.
2、mechanism of action
- During male sexual stimulation, the neuronal endings in the corpus cavernosum of the penis release nitric oxide (NO), which activates guanylate cyclase and increases cyclic guanosine phosphate (cGMP) levels, which leads to relaxation of smooth muscles and blood flows into the corpus cavernosum of the penis, causing erection.
- PDE5 is mainly found in smooth muscle cells of the corpus cavernosum of the penis. Tadalafil inhibits PDE5 and reduces the degradation of cGMP, thereby enhancing erectile function.
3、pharmacodynamic characteristics
- Tadalafil has a relatively long time of action. After oral administration, its effect can last for about 36 hours, so it is also called "weekend pills", which is different from some other short-acting PDE5 inhibitors.
2. Precautions for use
1、Applicable population and contraindications
- It is suitable for adult male patients with erectile dysfunction, but contraindicated for those who are allergic to tadalafil, and for patients who are taking any form of nitrates (such as nitroglycerin, etc.) because the combination of nitrates with tadalafil may cause severe hypotension.
2、adverse reactions
- Common adverse reactions include headache, indigestion, back pain, myalgia, flushing, etc. These adverse reactions are generally mild to moderate and are usually temporary.
3、Dosage and Administration
- It is generally taken as needed before sexual activity. Different product specifications may have different recommended doses, and there are also low-dose regular taking plans. For example, taking a small dose of tadalafil every day to improve erectile function. This method may be beneficial to some patients. Have better long-term results.
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