Tadalafil: A Drug for Male Erectile Dysfunction

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Gui í a de Salud Masculina

  1. 1. Mechanism of action
  2. two。 Drug characteristics
  3. 3. Usage and dosage
  4. 4. Matters needing attention

tadalafil (tadalafil) is a drug for the treatment of male erectile dysfunction (ED). It can also be used to treat symptoms of benign prostatic hyperplasia (BPH).

Mechanism of action

Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor.

Tadalafil: A Drug for Male Erectile Dysfunction

During sexual stimulation, neurons in the penile cavernous body release nitric oxide (NO). NO activates guanylate cyclase and increases the level of cyclic guanosine monophosphate (cGMP), causing smooth muscle relaxation and blood flow into penile tissue, resulting in an erection.

-PDE5 degrades cGMP, while tadalafil inhibits PDE5, which can maintain a high level of cGMP and enhance erectile function.

Drug characteristics

Long-term effectThe action time of tadalafil is longer, and its half-life is about 17.5 hours, which lasts longer than other similar drugs such as sildenafil. After taking tadalafil, within 36 hours, patients may have a better erectile effect under sexual stimulation.

ValidityA large number of clinical studies have shown that tadalafil has a good effect on erectile dysfunction caused by different causes, and can significantly improve the erectile function and quality of sexual life of patients.

Security.When used at the recommended dose, the overall safety is good. Common adverse reactions include headache, blushing, indigestion, nasal congestion, etc., which are usually mild and transient.

Usage and dosage

For the treatment of erectile dysfunction, the initial dose of 10mg is recommended when taken on demand and taken before sex. Depending on the individual's efficacy and tolerance, the dose can be increased to 20mg or reduced to 5mg.

For daily use, the recommended dose is 2.5mg, taking it at about the same time every day, regardless of when to have sex.

In the treatment of benign prostatic hyperplasia, the recommended dose is 5mg, once a day.

Matters needing attention

-patients who are taking any form of organic nitrates (such as nitroglycerin) should not use tadalafil because a combination of the two can lead to severe hypotension.

Patients with cardiovascular disease should consult their doctor, evaluate cardiovascular function and use it with caution before using tadalafil.


Darafei is usually taken within 30 minutes to an hour before sexual activity, and its effect can last up to 36 hours, which means that during that time, if there is enough sexual stimulation, the patient may be able to get and maintain an erection. Durafil does not automatically cause an erection, it needs sexual stimulation to work.

When using Dalafe, you need to pay attention to the following points:

1 、Do not use with nitrate drugs at the same timeBecause this can lead to a severe drop in blood pressure.

2. Avoid drinking too much, as alcohol may increase the side effects of drugs.

3. Consult your doctor in time if there are any discomfort or side effects, such as headache, flushing, indigestion, etc.

For certain groups of people, such as patients who are taking other drugs, with a history of cardiovascular disease or hypotension, darafei should be used under the guidance of a doctor.

Durafil is an effective drug for the treatment of male erectile dysfunction, but it needs to be used correctly under the guidance of doctors to ensure safety and effectiveness.

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