All You Need to Know about Tadalafil 20mg
I. basic information of drugs
1 、Name
-Tadalafil (tadalafil), 20mg is a common dose specification.
2 、Indication
Erectile dysfunction (ED)
Tadalafil improves penile erectile function by inhibiting phosphodiesterase 5 (PDE5) and increasing the vasodilation mediated by nitric oxide (NO) in the sponge. Tadalafil can help men obtain and maintain erection under sexual stimulation.
Pulmonary hypertension (PAH)
-at low doses (generally lower than 20mg), tadalafil can also be used to treat pulmonary hypertension by relaxing pulmonary vessels, reducing pulmonary vascular resistance and improving patients' exercise ability.
3 、Pharmacological mechanism
In the corpus cavernosum of the penis, sexual stimulation causes the release of nitric oxide (NO) from nerve endings and endothelial cells. NO activates guanosine cyclase and increases the synthesis of cyclic guanosine monophosphate (cGMP). CGMP can cause smooth muscle relaxation of the corpus cavernosum, blood flow into the cavernous body and lead to erection. Tadalafil can inhibit PDE5,PDE5 is the main enzyme for the degradation of cGMP, inhibition of PDE5 can increase the level of cGMP, thus enhancing erectile function.
-in the pulmonary artery, tadalafil also inhibits PDE5, increases the level of cGMP, relaxes pulmonary vascular smooth muscle and reduces pulmonary artery pressure.
II. Usage and matters needing attention
1 、Usage
impotence
-when taking 10mg on demand, it is recommended to take it before sex. Depending on the efficacy and tolerance of the individual, the dose can be increased to 20mg or reduced to 5mg. The maximum frequency of taking the drug is once a day, or you can choose to take a low dose regularly (2.5-5mg) daily, which may have a better effect on some patients. Especially for patients who want to have sex more naturally rather than taking medication as needed.
Pulmonary hypertension
-usually once a day, oral administration of 40mg (different from the dosage of erectile dysfunction).
2 、Matters needing attention
Cardiovascular aspect
Tadalafil has mild vasodilation and is prohibited for patients who are taking nitrates (such as nitroglycerin, isosorbide dinitrate, etc.), as a combination of the two may lead to severe hypotension. Patients with cardiovascular disease (such as unstable angina pectoris, recent myocardial infarction, etc.) need to carefully assess the risk when using tadalafil.
Visual aspect
-very few patients have reported non-arterial anterior ischemic optic neuropathy (NAION) after using tadalafil, a rare eye disease that can lead to vision loss or even blindness. if patients have eye diseases (such as retinitis pigmentosa, etc.) or have a history of vision problems, special care should be taken when using tadalafil.
Other
-tadalafil may interact with other drugs, such as some antifungal drugs (such as ketoconazole, itraconazole) and macrolide antibiotics (such as erythromycin), which may increase the blood concentration of tadalafil and increase the risk of adverse reactions. doctors should be informed of all drugs being used before using tadalafil.
Third, adverse reactions
1 、Common adverse reactions
HeadacheThis is one of the more common adverse reactions, which may be related to the vasodilation effect of tadalafil on blood vessels and affect the hemodynamics of cerebral vessels.
DyspepsiaSymptoms such as stomach discomfort, bloating and nausea are usually mild.
Back painSome patients may have low back pain, but the exact mechanism is not completely clear.
MyalgiaMuscle pain is also a possible adverse reaction, which may be related to the effect of drugs on muscle tissue.
2 、Other adverse reactions
-there may also be symptoms such as blushing, stuffy nose and dizziness, and in rare cases, adverse reactions such as severe allergic reactions and hypotension may occur.